Pr.François BERGER

François Berger- U1205-

BrainTech Lab director

François Berger, MD, PhD had a dual scientific and clinical education in the field of neurology, oncology and molecular and cell biology. He continues to have a dual clinical and research activity has professor of cell biology and neuro-oncology. He develops a translational research activity, trying to validate innovative technologies at the preclinical/clinical level in close collaboration with micro-nanotechnology groups. Exploring the best modalities to accelerate translation of technology innovation at the bedside is the main focus of his research. As Clinatec director he explored the feasibility of clinical research delocalization inside Minatec technology campus as an experimentation to accelerate translation of technology Innovation. Difficulties to export an academic research mode, cost to manage safely patients outside the hospital, the progressive migration to a techno-centric position and at the end the ethical questioning of this position were the main bottlenecks. The development of an innovative translational strategy to catch disruptive innovation outside the health sector was the main success in the context of CEA excellence in the field of technology. After two years, he came back inside the hospital as director of a new research unit INSERM U1205 associating INSERM-Grenoble University and Grenoble university hospital. He is now director of a new research unit INSERM U1205-BrainTech Lab. The objectives of this group are to develop innovative technologies for a better understanding and therapy of Brain diseases and cancer. It is also to accelerate the transfer of technology innovation at the bedside implementing innovating translational methodologies from cellular, preclinical investigations to human proof of concept trials.

Research area: neuro-oncology, neurosciences, biomarkers, nanomedicine

Education.

Institution                            Major           Degree                    Year

Poitiers Medical school      MD                                                 1990

Angers Medical school       Residency   neurologist             1994

San Diego Salk Institute     Postdoctoral fellowship in the

F Gage laboratory                      1995- 1997 (San Diego, US)

Grenoble University            PhD                                               1998

Grenoble university            Master of Science                        1995

Professional Career

2016: Director of the new INSERM research unit U1205-BrainTech Lab in Grenoble hospital.

2011-2014: director of Clinatec Lab INSERM UA 01 and CLINATEC INSTITUTE, CEA, Grenoble (Innovative Applications of Micro-Nano-Technologies to Medicine).

Since 2004: Head of the INSERM research laboratory “Brain nanomedicine group”

Since 2000: Professor of Cell Biology and Oncology- clinical activity in the field of neuro-oncology

1999-2004: Head of the neuro-oncology group in the INSERM research laboratory of AL Benabid.

1994- 1995        Assistant in cell biology and neuro-oncology

FELLOWSHIPS, AWARDS

– 1989:                            Residency gold Medal.

– 1995:                            Michel Clavel Prize

– 2015:                            Biovision Prize for innovation

– 2015:                            French startup innovation Prize for the creation of Medimprint.

Representative publications

– Zaccaria A, Bouamrani A, Chabardès S, El Atifi M, Seigneuret E, Lobrinus JA,Dubois-Dauphin M, Berger F, Burkhard PR (co-last authors) . Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson’s disease. Mol Neurodegener. 2016 Jan 28;11:12.

– Accessing to the minor proteome of red blood cells through the influence of the nanoparticle surface properties on the corona compositionZaccaria A, Roux-Dalvai F, Bouamrani A, Mombrun A, Mossuz P, Monsarrat B, Berger F. International Journal of Nanomedicine 2015, 10:1869-1883.

-Vilgrain I, Sidibé A, Polena H, Cand F, Mannic T, Arboleas M, Boccard S, Baudet A, Gulino-Debrac D, Bouillet L, Quesada JL, Mendoza C, Lebas JF, Pelletier L, Berger F. Evidence for post-translational processing of vascular endothelial (VE)-cadherin in brain tumors: towards a candidate biomarker. PLoS One. 2013 Dec 16;8(12):e80056.

-Selek L, Seigneuret E, Nugue G, Wion D, Nissou MF, Salon C, Seurin MJ, Carozzo C, Ponce F, Roger T, Berger F. Imaging and histological characterization of a human brain xenograft in pig: the first induced glioma model in a large animal. J Neurosci Methods. 2014 Jan 15;221:159-65.

– Zaccaria A, Bouamrani A, Selek L, El Atifi M, Hesse AM, Juhem A, Ratel D, Mathieu H, Coute Y, Bruley C, Garin J, Benabid AL, Chabardes S, Piallat B, Berger F. A micro-silicon chip for in vivo cerebral imprint in monkey. ACS Chem Neurosci. 2013 Mar 20;4(3):385-92.

International patents in the field of nanoproteomic, micro-invasive molecular fingerprints and biomarkers